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DeSmuMe is one of the best emulators for the handheld Nintendo DS console (and Game Boy Advance) that you can find. It lets you use your PC to play the majority of DS games, improving the gaming experience even beyond that of the original console.
The emulator can display both screens of the console simultaneously. The lower one, which corresponds to the touchscreen, can be used with the mouse, while the traditional pad controls can be used with the keyboard or with an external USB gamepad. This way, you can play all the classics, like New Super Mario Bros, Pokemon White/Black, Animal Crossing, or the first games with Professor Layton. You can also use post-processing filters to improve the graphics.
You can save the games at any time, take screenshots and videos of the games, and use advanced tools to rip content.